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KMID : 0617319940040010107
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Journal of Pharmacetical Sceiences Ewha Womans University
1994 Volume.4 No. 1 p.107 ~ p.112
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TISSUE CONCENTRATION OF XYLAZINE AND ITS METABOLITES IN RATS
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Abstract
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Xylazine has been used as tranquilizer for food producing animals. The concentration of xylazine and its metabolites in major organs are determined for the safety of meat. Xylazine was eliminated very rapidly as reported and not detected after 10 hrs in organs. However p-hydroxy-xylazine, a main metabolite of xylazine in urine, was detected in liver in the concentration of 0.37~2.58㎎/g tissue to 48hrs. 2.6-Dimethylisothiocyanate, another metabolite of xylazine and a possible toxicant, was detected in low concentration to 2hrs in liver, kidney and muscle. This metabolite distributed in organs easily because of its higher lipophilicity than p-hydroxylated metabolite.
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KEYWORD
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